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1

Inverse agonism at G protein-coupled receptors: (patho)physiological relevance and implications for drug discovery

Rianne A F De Ligt, Angeliki P Kourounakis, Ad P IJzerman

Journal:

British Journal of Pharmacology

Year:

2000

Language:

english

File:

PDF, 196 KB

english, 2000

2

5‘- O -Alkyl Ethers of N ,2-Substituted Adenosine Derivatives: Partial Agonists for the Adenosine A 1 and A 3 Receptors

van Tilburg, Erica W., van der Klein, Pieter A. M., von Frijtag Drabbe Künzel, Jacobien, de Groote, Miriam, Stannek, Christina, Lorenzen, Anna, IJzerman, Ad P.

Journal:

Journal of Medicinal Chemistry

Year:

2001

Language:

english

File:

PDF, 121 KB

english, 2001

3

Evolutionary Algorithms in Drug Design

Eric-Wubbo Lameijer, Thomas Bäck, Joost N. Kok, AD P. Ijzerman

Journal:

Natural Computing

Year:

2005

Language:

english

File:

PDF, 495 KB

english, 2005

4

Cyclopentyladenosine and some of its low-efficacy derivatives inhibit striatal synaptosomal release of acetylcholine to a similar degree

Tjerk J.H. Bueters, Leonie M. van Duivenvoorde, Meindert Danhof, Ad P. IJzerman, Herman P.M. van Helden

Journal:

European Journal of Pharmacology

Year:

2003

Language:

english

File:

PDF, 207 KB

english, 2003

5

Principles of agonism: undressing efficacy

Thue W Schwartz, Ad P Ijzerman

Journal:

Trends in Pharmacological Sciences

Year:

1998

Language:

english

File:

PDF, 472 KB

english, 1998

6

Derivatives of the Triazoloquinazoline Adenosine Antagonist (CGS 15943) Having High Potency at the Human A 2B and A 3 Receptor Subtypes

Kim, Yong-Chul, de Zwart, Maarten, Chang, Louis, Moro, Stefano, von Frijtag Drabbe Künzel, Jacobien K., Melman, Neli, IJzerman, Ad P., Jacobson, Kenneth A.

Journal:

Journal of Medicinal Chemistry

Year:

1998

Language:

english

File:

PDF, 202 KB

english, 1998

7

[ACM Press the 2005 conference - Washington DC, USA (2005.06.25-2005.06.29)] Proceedings of the 2005 conference on Genetic and evolutionary computation - GECCO '05 - The molecule evoluator

Lameijer, Eric-Wubbo, IJzerman, Ad, Kok, Joost

Year:

2005

Language:

english

File:

PDF, 310 KB

english, 2005

8

Synthesis and evaluation of homodimeric GnRHR antagonists having a rigid bis-propargylated benzene core

Kimberly M. Bonger, Richard J.B.H.N. van den Berg, Annemiek D. Knijnenburg, Laura H. Heitman, Ad P. IJzerman, Julia Oosterom, Cornelis M. Timmers, Herman S. Overkleeft, Gijsbert A. van der Marel

Journal:

Bioorganic & Medicinal Chemistry

Year:

2008

Language:

english

File:

PDF, 364 KB

english, 2008

9

Cell-free MicroRNA miR-505-3p in Graft Preservation Fluid Is an Independent Predictor of Delayed Graft Function After Kidney Transplantation

Roest, Henk P., Ooms, Liselotte S.S., Gillis, Ad J.M., IJzermans, Jan N.M., Looijenga, Leendert H.J., Dorssers, Lambert C.J., Dor, Frank J.M.F., van der Laan, Luc J.W.

Journal:

Transplantation Journal

Year:

2019

File:

PDF, 380 KB

2019

10

LUF7244 plus Dofetilide Rescues Aberrant K v 11.1 Trafficking and Produces Functional I Kv11.1

Qile, Muge, Ji, Yuan, Golden, Tyona D., Houtman, Marien J.C., Romunde, Fee, Fransen, Doreth, van Ham, Willem B., IJzerman, Ad P., January, Craig T., Heitman, Laura H., Stary-Weinzinger, Anna, Delisle,

Journal:

Molecular Pharmacology

Year:

2020

File:

PDF, 13.30 MB

2020

11

ChemInform Abstract: Small Molecule Antagonists for Chemokine CCR3 Receptors

Lianne I. Willems, Ad P. Ijzerman

Journal:

Year:

2010

File:

PDF, 20 KB

2010

12

A “locked-on,” constitutively active mutant of the adenosine A1 receptor

Rianne A.F. de Ligt, Scott A. Rivkees, Anna Lorenzen, Rob Leurs, Ad P. IJzerman

Journal:

European Journal of Pharmacology

Year:

2005

Language:

english

File:

PDF, 164 KB

english, 2005

13

N 6 ,5‘-Disubstituted Adenosine Derivatives as Partial Agonists for the Human Adenosine A 3 Receptor

van Tilburg, Erica W., von Frijtag Drabbe Künzel, Jacobien, de Groote, Miriam, Vollinga, Roel C., Lorenzen, Anna, IJzerman, Ad P.

Journal:

Journal of Medicinal Chemistry

Year:

1999

Language:

english

File:

PDF, 129 KB

english, 1999

14

A novel selective inverse agonist of the CB2 receptor as a radiolabeled tool compound for kinetic binding studies

Martella, Andrea, Sijben, Huub, Rufer, Arne, Fingerle, Juergen, Grether, Uwe, Ullmer, Christoph, Hartung, Thomas, IJzerman, Ad, van der Stelt, Mario, Heitman, Laura

Journal:

Molecular Pharmacology

Year:

2017

Language:

english

File:

PDF, 1.57 MB

english, 2017

15

Pharmacokinetic-Pharmacodynamic Analysis of the EEG Effect of Alfentanil in Rats Followingβ-Funaltrexamine-Induced μOpioid Receptor “Knockdown”In Vivo

>Maria Garrido, Josy Gubbens-Stibbe, Erica Tukker, Eugégne Cox, Jacobien von Frijtag, DrabbeM Künzel, Ad IJzerman, Meindert Danhof, Piet H. van der Graaf

Journal:

Pharmaceutical Research

Year:

2000

Language:

english

File:

PDF, 203 KB

english, 2000

16

The antiarrhythmic properties of β-adrenoceptor antagonists

Ad P. Ijzerman, Willem Soudijn

Journal:

Trends in Pharmacological Sciences

Year:

1989

Language:

english

File:

PDF, 923 KB

english, 1989

17

Effects of the adenosine A1 receptor allosteric modulators PD 81,723 and LUF 5484 on the striatal acetylcholine release

Tjerk J.H Bueters, Herman P.M van Helden, Meindert Danhof, Ad P IJzerman

Journal:

European Journal of Pharmacology

Year:

2002

Language:

english

File:

PDF, 126 KB

english, 2002

18

Structural Aspects of Bile Acids Involved in the Regulation of Cholesterol 7α-Hydroxylase and Sterol 27-Hydroxylase

Jaap Twisk, Marco F. M. Hoekman, Linda M. Muller, Takashi Iida, Tamaaki Tamaru, Ad Ijzerman, Willem H. Mager, Hans M. G. Princen

Journal:

Year:

1995

Language:

english

File:

PDF, 1.01 MB

english, 1995

19

Allosteric modulation of G-protein-coupled receptors

IJzerman, Ad P, Wijngaarden, Ineke van, Soudijn, Willem

Journal:

Expert Opinion on Therapeutic Patents

Year:

2001

Language:

english

File:

PDF, 216 KB

english, 2001

20

Characteristic amino acid combinations in olfactory G protein-coupled receptors

Elena V. Samsonova, Peter Krause, Thomas Bäck, Ad P. IJzerman

Journal:

Proteins: Structure, Function, and Bioinformatics

Year:

2007

Language:

english

File:

PDF, 634 KB

english, 2007

21

Involvement of Asn-293 in Stereospecific Agonist Recognition and in Activation of the β2-Adrenergic Receptor

Kerstin Wieland, Helene M. Zuurmond, Cornelius Krasel, Ad P. Ijzerman and Martin J. Lohse

Journal:

Proceedings of the National Academy of Sciences

Year:

1996

Language:

english

File:

PDF, 1.07 MB

english, 1996

22

Broadband mean free path of diffuse light in polydisperse ensembles of scatterers for white light-emitting diode lighting

Vos, Willem L., Tukker, Teus W., Mosk, Allard P., Lagendijk, Ad, IJzerman, Wilbert L.

Journal:

Year:

2013

Language:

english

File:

PDF, 936 KB

english, 2013

23

The adhesion G protein-coupled receptor G2 (ADGRG2/GPR64) constitutively activates SRE and NFκB and is involved in cell adhesion and migration

Peeters, Miriam C., Fokkelman, Michiel, Boogaard, Bob, Egerod, Kristoffer L., van de Water, Bob, IJzerman, Ad P., Schwartz, Thue W.

Journal:

Cellular Signalling

Year:

2015

Language:

english

File:

PDF, 1.27 MB

english, 2015

24

Elucidation of structure–activity relationships of 2-amino-3-benzoylthiophenes: Study of their allosteric enhancing vs. antagonistic activity on adenosine A1 receptors

Angeliki P. Kourounakis, Pieter A.M. Van der Klein, Ad P. Ijzerman

Journal:

Drug Development Research

Year:

2000

Language:

english

File:

PDF, 243 KB

english, 2000

25

Allosteric modulation and constitutive activity of fusion proteins between the adenosine A1 receptor and different 351Cys-mutated Gi α-subunits

Elisabeth Klaasse, Rianne A.F. de Ligt, Sophie F. Roerink, Anna Lorenzen, Graeme Milligan, Rob Leurs, Ad P. IJzerman

Journal:

European Journal of Pharmacology

Year:

2004

Language:

english

File:

PDF, 191 KB

english, 2004

26

A yeast screening method to decipher the interaction between the adenosine A2Breceptor and the C-terminus of different G protein α-subunits

Liu, Rongfang, Groenewoud, Nick J. A., Peeters, Miriam C., Lenselink, Eelke B., IJzerman, Ad P.

Journal:

Purinergic Signalling

Year:

2014

Language:

english

File:

PDF, 908 KB

english, 2014

27

Synthesis and evaluation of homo-bivalent GnRHR ligands

Kimberly M. Bonger, Richard J.B.H.N. van den Berg, Laura H. Heitman, Ad P. IJzerman, Julia Oosterom, Cornelis M. Timmers, Herman S. Overkleeft, Gijsbert A. van der Marel

Journal:

Bioorganic & Medicinal Chemistry

Year:

2007

Language:

english

File:

PDF, 360 KB

english, 2007

28

Allosteric modulators affect the internalization of human adenosine A1 receptors

Elisabeth C. Klaasse, Gijs van den Hout, Sophie F. Roerink, Willem J. de Grip, Ad P. IJzerman, Margot W. Beukers

Journal:

European Journal of Pharmacology

Year:

2005

Language:

english

File:

PDF, 246 KB

english, 2005

29

Pharmacology of purinergic receptors: implications for drug design: Noordwijk, Netherlands 6–8 July 1990

Ad Ijzerman, Philip van Galen

Journal:

Trends in Pharmacological Sciences

Year:

1990

Language:

english

File:

PDF, 208 KB

english, 1990

30

Molecular modeling of adenosine receptors. The ligand binding site on the rat adenosine A2A receptor

Ad P. Ijzerman, Eleonora M. van der Wenden, Philip J.M. van Galen, Kenneth A. Jacobson

Journal:

European Journal of Pharmacology: Molecular Pharmacology

Year:

1994

Language:

english

File:

PDF, 1014 KB

english, 1994

31

Pyrido[2,1-f]purine-2,4-dione Derivatives as a Novel Class of Highly Potent Human A3 Adenosine Receptor Antagonists

Priego, Eva-María, von Frijtag Drabbe Kuenzel, Jacobien, IJzerman, Ad P., Camarasa, María-José, Pérez-Pérez, María-Jesús

Journal:

Journal of Medicinal Chemistry

Year:

2002

Language:

english

File:

PDF, 150 KB

english, 2002

32

The mode of interaction of amiloride and some of its analogues with the adenosine A1 receptor

Garritsen, Anja, Beukers, Margot W., Ijzerman, Ad P., Cragoe Jr, Edward J., Soudijn, Willem

Journal:

Neurochemistry International

Year:

1992

Language:

english

File:

PDF, 586 KB

english, 1992

33

TLR-Induced IL-12 and CCL2 Production by Myeloid Cells Is Dependent on Adenosine A 3 Receptor–Mediated Signaling

van der Putten, Céline, Veth, Jennifer, Sukurova, Lejla, Zuiderwijk-Sick, Ella A., Simonetti, Elles, Koenen, Hans J. P .M., Burm, Saskia M., van Noort, Johannes M., IJzerman, Ad P., van Hijum, Sacha A

Journal:

The Journal of Immunology

Year:

2019

Language:

english

File:

PDF, 1.12 MB

english, 2019

34

Radical scavenging properties of adenosine and derivatives in vitro

Jacobien K. von Frijtag Drabbe Künzel, Jolanda van der Zee, Ad P. Ijzerman

Journal:

Drug Development Research

Year:

1996

Language:

english

File:

PDF, 585 KB

english, 1996

35

Extracellular adenosine-induced apoptosis in mouse neuroblastoma cells studies on involvement of adenosine receptors and adenosine uptake

S.Mariette Schrier, Erica W van Tilburg, Hans van der Meulen, Ad P Ijzerman, Gerald J Mulder, J.Fred Nagelkerke

Journal:

Biochemical Pharmacology

Year:

2001

Language:

english

File:

PDF, 433 KB

english, 2001

36

Early treatment of trans-tibial amputees: retrospective analysis of early fitting and elastic bandaging

Van Velzen, AD, Nederhand, MJ, Emmelot, CH, Ijzerman, MJ

Journal:

Prosthetics & Orthotics International

Year:

2005

Language:

english

File:

PDF, 75 KB

english, 2005

37

The kinetics of the binding of warfarin to human serum albumin as studied by stopped-flow spectrophotometry

Jaap Wilting, Josephina M.H. Kremer, Ad P. Ijzerman, Stephen G. Schulman

Journal:

Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology

Year:

1982

Language:

english

File:

PDF, 690 KB

english, 1982

38

Functional selectivity of adenosine A1receptor ligands?

Langemeijer, Ellen V., Verzijl, Dennis, Dekker, Stefan J., IJzerman, Ad P.

Journal:

Purinergic Signalling

Year:

2013

Language:

english

File:

PDF, 374 KB

english, 2013

39

N 6 ,C8-Disubstituted Adenosine Derivatives as Partial Agonists for Adenosine A 1 Receptors †

Roelen, Harlof, Veldman, Nora, Spek, Anthony L., von Frijtag Drabbe Künzel, Jacobien, Mathôt, Ron A. A., IJzerman, Ad P.

Journal:

Journal of Medicinal Chemistry

Year:

1996

Language:

english

File:

PDF, 255 KB

english, 1996

40

Mining a Chemical Database for Fragment Co-occurrence: Discovery of “Chemical Clichés”

Lameijer, Eric-Wubbo, Kok, Joost N., Bäck, Thomas, IJzerman, Ad P.

Journal:

Journal of Chemical Information and Modeling

Year:

2006

Language:

english

File:

PDF, 163 KB

english, 2006

41

[IEEE 2013 Conference on Lasers & Electro-Optics Europe & International Quantum Electronics Conference CLEO EUROPE/IQEC - Munich, Germany (2013.05.12-2013.05.16)] 2013 Conference on Lasers & Electro-Optics Europe & International Quantum Electronics Conference CLEO EUROPE/IQEC - Broadband multiple light scattering in white LED diffusers

Vos, Willem L., Tukker, Teus W., Mosk, Allard P., Lagendijk, Ad, IJzerman, Wilbert L.

Year:

2013

Language:

english

File:

PDF, 233 KB

english, 2013

42

The beta-adrenoceptor-adenylate cyclase complex

Ad P. Ijzerman, Henk Timmerman

Journal:

International Journal of Clinical Pharmacy

Year:

1986

Language:

english

File:

PDF, 1.35 MB

english, 1986

43

The endocannabinoid 2-arachidonylglycerol is a negative allosteric modulator of the human A3 adenosine receptor

J. Robert Lane, Margot W. Beukers, Thea Mulder-Krieger, Ad P. IJzerman

Journal:

Biochemical Pharmacology

Year:

2010

Language:

english

File:

PDF, 447 KB

english, 2010

44

Mutational analysis of the putative devazepide binding site of the CCKA receptor

Rolf L.L Smeets, Ad P IJzerman, Harm P.H Hermsen, Olga J.A.E Ophorst, Sjenet E Van Emst-de Vries, Jan Joep H.H.M De Pont, Peter H.G.M Willems

Journal:

European Journal of Pharmacology

Year:

1997

Language:

english

File:

PDF, 239 KB

english, 1997

45

5‘- N -Substituted Carboxamidoadenosines as Agonists for Adenosine Receptors

de Zwart, Maarten, Kourounakis, Angeliki, Kooijman, Huub, Spek, Anthony L., Link, Regina, von Frijtag Drabbe Künzel, Jacobien K., IJzerman, Ad P.

Journal:

Journal of Medicinal Chemistry

Year:

1999

Language:

english

File:

PDF, 115 KB

english, 1999

46

A Functional Screening of Adenosine Analogues at the Adenosine A 2B Receptor: A Search for Potent Agonists

de Zwart, Maarten, Link, Regina, von Frijtag Drabbe Kunzela, Jacobien K., Cristalli, Gloria, Jacobson, Kenneth A., Townsend-Nicholson, Andrea, IJzerman, Ad P.

Journal:

Nucleosides and Nucleotides

Year:

1998

Language:

english

File:

PDF, 695 KB

english, 1998

47

Small molecule antagonists for chemokine CCR3 receptors

Lianne I. Willems, Ad P. IJzerman

Journal:

Medicinal Research Reviews

Year:

2010

Language:

english

File:

PDF, 648 KB

english, 2010

48

Characterization of the pharmacokinetics, brain distribution, and therapeutic efficacy of the adenosine A1 receptor partial agonist 2′-deoxy-N6-cyclopentyladenosine in sarin-poisoned rats

Tjerk J.H Bueters, Ad P IJzerman, Herman P.M van Helden, Meindert Danhof

Journal:

Toxicology and Applied Pharmacology

Year:

2003

Language:

english

File:

PDF, 149 KB

english, 2003

49

New, Non-Adenosine, High-Potency Agonists for the Human Adenosine A 2B Receptor with an Improved Selectivity Profile Compared to the Reference Agonist N -Ethylcarboxamidoadenosine

Beukers, Margot W., Chang, Lisa C. W., von Frijtag Drabbe Künzel, Jacobien K., Mulder-Krieger, Thea, Spanjersberg, Ronald F., Brussee, Johannes, IJzerman, Ad P.

Journal:

Journal of Medicinal Chemistry

Year:

2004

Language:

english

File:

PDF, 54 KB

english, 2004

50

Chemogenomics Approaches for Receptor Deorphanization and Extensions of the Chemogenomics Concept to Phenotypic Space

van der Horst, Eelke, E. Peironcely, Julio, J. P. van Westen, Gerard, O. van den Hoven, Olaf, R. J. D. Galloway, Warren, R. Spring, David, K. Wegner, Joerg, W. T. van Vlijmen, Herman, P. IJzerman, Ad,

Journal:

Current Topics in Medicinal Chemistry

Year:

2011

Language:

english

File:

PDF, 573 KB

english, 2011

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